Figure 2.
Interaction of VWF domains with LRP1 cluster II and cluster IV. (A) Overview of the recombinant truncated VWF constructs studied. (B) Binding of full-length rVWF (red), VWF-D’A3 (blue), and VWF-A1A2A3 (green) to purified LRP1 cluster IV. (C) Binding of full-length rVWF (red), VWF-D’A3 (blue), and VWF-A1A2A3 (green) to LRP1 cluster II. (D) Binding of individual VWF-A1 (red), VWF-A2 (blue), and VWF-A3 (green) domains to LRP1 cluster IV. (E) Binding of individual VWF-A1 (red), VWF-A2 (blue), and VWF-A3 (green) domains to LRP1 cluster II. Dots represent mean absorbance at 450 nm at corresponding VWF concentrations. Error bars depict standard deviations. P values are outcomes of extra-sum-of-squares F test and compare the binding capacity of different VWF constructs with LRP1 cluster IV or cluster II. Abs, absorbance.

Interaction of VWF domains with LRP1 cluster II and cluster IV. (A) Overview of the recombinant truncated VWF constructs studied. (B) Binding of full-length rVWF (red), VWF-D’A3 (blue), and VWF-A1A2A3 (green) to purified LRP1 cluster IV. (C) Binding of full-length rVWF (red), VWF-D’A3 (blue), and VWF-A1A2A3 (green) to LRP1 cluster II. (D) Binding of individual VWF-A1 (red), VWF-A2 (blue), and VWF-A3 (green) domains to LRP1 cluster IV. (E) Binding of individual VWF-A1 (red), VWF-A2 (blue), and VWF-A3 (green) domains to LRP1 cluster II. Dots represent mean absorbance at 450 nm at corresponding VWF concentrations. Error bars depict standard deviations. P values are outcomes of extra-sum-of-squares F test and compare the binding capacity of different VWF constructs with LRP1 cluster IV or cluster II. Abs, absorbance.

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