Relationship of pituitary R2 z score with follicle-stimulating hormone (FSH) and total pituitary volume. (A) FSH (mIU/mL) decreases with increasing pituitary iron concentration, expressed as pituitary R2 z score. (B) Total pituitary volume decreases as a function of pituitary iron. Both total volume and pituitary R2 are expressed as age and sex appropriate z scores.