Discrepancy between fibrinogen Clauss activity and MS level persists throughout acute and subacute severe injury. (A) Time series plot of Clauss fibrinogen activity displaying median activity ± IQR by ST group across time. Green is HC median level ± IQR. (B) Time series plot of MS fibrinogen levels displaying median levels ± IQR by ST group across time. Green is HC median level ± IQR. (C-F) Clauss fibrinogen activity and MS fibrinogen levels at ED and hour 6 after injury by ST group. Significance determined as ∗∗P < .005, ∗∗∗∗P < .0005 by Kruskal-Wallis test.