Impact of the induction chemotherapy regimen. (A) Rates of remission, PC2 MRD negativity, and relapse from MRD^– state, by induction chemotherapy regimen. (B) Kaplan-Meier curve of OS in all patients with NPM1^mut, by induction chemotherapy regimen. (C) CIR in all patients with NPM1 mutant, by induction chemotherapy regimen. (D) BM NPM1 MRD copy number (per 10⁵ copies ABL1) after each course of chemotherapy, by induction chemotherapy regimen. ns, not significant. ∗∗∗P < .001; ∗∗∗∗P < .0001.