Functional impact of postgain deletions. Left column: copy-number plot. Right column: bulk RNAseq transcript for each involved gene. The green dot denotes transcript levels for the patients represented in copy-number plots. (A) Postgain deletion near the oncogene BCL2 led to a GOF. (B) Postgain deletion led to a gene fusion. (C) Postgain deletion involving TSG ATM led to gene expression downregulation (ie, LOF) despite having 2 remaining alleles. GOF, gain-of-function.