Figure 5.
Postgain deletion prevalence and functional impact in patients with newly diagnosed and relapsed RM. (A) Cumulative distribution plot of 382 MM samples with postgain deletions. Top of the plot shows TSGs and oncogenes that were enriched with more than the median number of patients per 1 Mb bin having a postgain deletion on the given chromosome. (B) Enlarged distribution of postgain deletions per 1 Mb bin on chromosome 1 with involvement of the TSGs CDKN2C and FAM46C. (C) Enlarged distribution of postgain deletions per 1 Mb bin on chromosome 9 with involvement of the TSG CDKN2A. (D) CNV plot showing a postgain deletion near BCL6 in NDMM patient MMRF_1738. (E) RNAseq transcript levels of NDMM patients from the MMRF study with patient MMRF_1738 highlighted in green, showing overexpression.

Postgain deletion prevalence and functional impact in patients with newly diagnosed and relapsed RM. (A) Cumulative distribution plot of 382 MM samples with postgain deletions. Top of the plot shows TSGs and oncogenes that were enriched with more than the median number of patients per 1 Mb bin having a postgain deletion on the given chromosome. (B) Enlarged distribution of postgain deletions per 1 Mb bin on chromosome 1 with involvement of the TSGs CDKN2C and FAM46C. (C) Enlarged distribution of postgain deletions per 1 Mb bin on chromosome 9 with involvement of the TSG CDKN2A. (D) CNV plot showing a postgain deletion near BCL6 in NDMM patient MMRF_1738. (E) RNAseq transcript levels of NDMM patients from the MMRF study with patient MMRF_1738 highlighted in green, showing overexpression.

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