Defining the germinal center origin of t(11;14)(CCND1;IGH) in MM. (A) Showing the mean SNV burden per megabase (Mb) on chromosomes 18 and 14 in DLBCL and FL samples with t(14;18)(IGH;BCL2). The rightmost plots in each row show intermutational distance (IMD) of SNV in a single patient on chromosome 18. The BCL2 region is indicated by vertical red lines. (B-C) Mean SNV burden per Mb on chromosomes 11 and 14 in patients with MCL with a mutated IGHV region (M-IGHV) (B) and unmutated IGHV region (UM-IGHV) (C) on chromosome 14. The rightmost plot in each row shows IMD of SNV in a single patient from each group (M-IGHV or UM-IGHV) on chromosome 11. The CCND1 region is indicated by vertical red lines. (D-E) Mean SNV burden per Mb on chromosomes 11 and 14 in NDMM samples with t(11;14)(CCND1;IGH) in VDJ region and CSR region (D) and class-switch recombination (E). Rightmost plot in panels A-E shows IMD of SNV in a single patient from each group (VDJ or CSR) on chromosome 11. The CCND1 region is indicated by vertical red lines. (F) Proposed model behind the acquisition of CCND1 and BCL2 translocations in MM and B-cell lymphomas. (G) RAG RSS-motif analysis of SVs according to different categories as follows: CSR or VDJ region on chromosome 14 (RAG negative and positive controls, respectively), pregain deletion, postgain deletion, t(11;14)(CCND1;IGH) on chromosome 14 VDJ region, t(11;14)(CCND1;IGH) on chromosome 14 CSR region, or somatic (all other SV).