Cohort-wide copy-number profile and pre-/postgain deletions in MM. (A) Cumulative copy number plot summarizing the copy number distribution across the 3 series of MM. (B) Proportion of samples with SV-mediated pregain (yellow) and postgain (green) deletions according to different categories. MolTime: Samples with early gains determined by molecular time analysis. Pregain deletions include only NDMM samples, whereas postgain deletions include NDMM and RRMM samples.