HGBCL-DH-BCL2 tumors are frequently class switched. (A) Constant gene usage predicted from RNAseq data with MiXCR across lymphoma entities. The x-axis indicates the percent of tumors within each entity, whereas numbers at each bar indicate the absolute number of tumors predicted to use each constant gene. (B) The proportion of each lymphoma entity with predicted CSR (IGH constant gene other than IGHM or IGHD). The frequency of CSR between entities was compared with FDR-corrected pairwise Fisher exact tests. ∗∗P < .01; ∗∗∗∗P < .0001. (C) Constant gene usage in HGBCL-DH-BCL2 stratified by MYC-R partner.