Figure 5. Clonal relapse dynamics of... | American Society of Hematology

Figure 5.

Clonal relapse dynamics of patients based on detectable DTA and non-DTA molecular markers. Relapse DTA (DNMT3A, TET2, ASXL1) and non-DTA mutations were, if possible, repetitively monitored by NGS-MRD. Total number of prerelapse NGS analyses of DTA mutations: n = 69; median, 1; range, 1-5. Total number of prerelapse NGS analyses of non-DTA-mutations: n = 227; median, 1; range, 1-6. $f (x) = 0.98 + 0.5 x + 0.13 x^{2} + 0.02 x^{3} - 0.0009 x^{4} - 0.00002 x^{5}$ ⁠, $f (x_{D T A}) = 0.97 + 0.4 x_{D T A} + 0.06 x_{D T A}^{2} + 0.005 x_{D T A}^{3} - 0.0002 x_{D T A}^{4} - 0.00002 x_{D T A}^{5}$ ⁠.

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