Overview of patient samples and disease course. x axis: time before relapse, which is designated time t = 0. y axis: number of relapsed patients with AML. Orange circles: time of hematological relapse; green crosses: time of alloHCT; blue circles: MRD-negative samples; red circles: MRD-positive samples; purple circles: time of AML diagnosis; black lines: time from AML diagnosis to relapse; red lines connect positive samples and mark the time interval when patients are considered MRD positive.