Figure 1.
Proposed mechanism of tissue injury mediated by Mylotarg. (A) SOS is induced in the liver when FcγRIIb on LSECs mediates internalization of monomers or aggregates of ADC such as Mylotarg. The LSECs are killed by the ADC toxic payload.48-53 (B) Platelets bind ADC aggregates via FcγRIIa and are localized to the liver. LSEC take up and internalize the ADCs via FcγRIIb and are killed by the cytotoxic payload. It is not clear whether the platelets return to the circulation. Alternatively, monocytes and/or neutrophils (PMN) phagocytose the opsonized platelets via FcγRIII.54,55 Figure created with BioRender.com.

Proposed mechanism of tissue injury mediated by Mylotarg. (A) SOS is induced in the liver when FcγRIIb on LSECs mediates internalization of monomers or aggregates of ADC such as Mylotarg. The LSECs are killed by the ADC toxic payload.48-53 (B) Platelets bind ADC aggregates via FcγRIIa and are localized to the liver. LSEC take up and internalize the ADCs via FcγRIIb and are killed by the cytotoxic payload. It is not clear whether the platelets return to the circulation. Alternatively, monocytes and/or neutrophils (PMN) phagocytose the opsonized platelets via FcγRIII.54,55 Figure created with BioRender.com.

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