Figure 5.
Changes in serum immunoglobulin levels and IRT throughout treatment with leniolisib. (A) Individual and mean IgM values over time. n values for part 1 baseline, Ext Scr, and years 1, 2, 3, 4, 5, and 6 are as follows: 6, 6, 6, 6, 6, 6, 3, and 5, respectively. (B) Individual and mean IgA values over time. n values for part 1 baseline, Ext Scr, and years 1, 2, 3, 4, 5, and 6 are as follows: 6, 6, 6, 6, 6, 6, 2, and 5, respectively. (C) Individual and mean IgE values over time. The graph on the far left illustrates all individual and mean IgE values over time. The far-right portion depicts individual IgE values for P1 through P4 over time as indicated by the dotted lines. n values for part 1 baseline, Ext Scr, and years 1, 2, 3, 4, 5, and 6 are as follows: 6, 6, 6, 5, 6, 6, 2, and 5, respectively. (D) Individual and mean IgG values over time. n values for part 1 baseline, Ext Scr, and years 1, 2, 3, 4, 5, and 6 are as follows: 5, 6, 6, 6, 6, 6, 3, and 5, respectively. For values that were <, the actual number was entered to graph data. IRT usage in (E) P1, (F) P2, (G) P3, (H) P5, and (I) P6 over time. Day 0 is the DFT baseline. Gray boxes in panels A-D indicate age-matched normal ranges from LabCorp.31-34 Error bars are ± standard error of the mean.

Changes in serum immunoglobulin levels and IRT throughout treatment with leniolisib. (A) Individual and mean IgM values over time. n values for part 1 baseline, Ext Scr, and years 1, 2, 3, 4, 5, and 6 are as follows: 6, 6, 6, 6, 6, 6, 3, and 5, respectively. (B) Individual and mean IgA values over time. n values for part 1 baseline, Ext Scr, and years 1, 2, 3, 4, 5, and 6 are as follows: 6, 6, 6, 6, 6, 6, 2, and 5, respectively. (C) Individual and mean IgE values over time. The graph on the far left illustrates all individual and mean IgE values over time. The far-right portion depicts individual IgE values for P1 through P4 over time as indicated by the dotted lines. n values for part 1 baseline, Ext Scr, and years 1, 2, 3, 4, 5, and 6 are as follows: 6, 6, 6, 5, 6, 6, 2, and 5, respectively. (D) Individual and mean IgG values over time. n values for part 1 baseline, Ext Scr, and years 1, 2, 3, 4, 5, and 6 are as follows: 5, 6, 6, 6, 6, 6, 3, and 5, respectively. For values that were <, the actual number was entered to graph data. IRT usage in (E) P1, (F) P2, (G) P3, (H) P5, and (I) P6 over time. Day 0 is the DFT baseline. Gray boxes in panels A-D indicate age-matched normal ranges from LabCorp.31-34 Error bars are ± standard error of the mean.

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