Number of infections over time. Mean number of infections before and throughout exposure to leniolisib. n values for before leniolisib and years 1, 2, 3, 4, 5, and 6 are as follows: 6, 6, 6, 6, 6, 6, and 5, respectively. “Before leniolisib” comprises multiple years of recurrent/unresolved infection history. Post-leniolisib exposure includes only acute infections. Dotted line separates infections that occurred before and during treatment with leniolisib. Error bars are ± standard error of the mean.