Changes in HRQoL over time. (A) Normed subscale and component scores from the SF-36 survey, with higher scores indicating greater HRQoL.²⁶ MIDs for patients with IEI are from the literature.²⁵ The latest time point for P1, P2, P3, P4, P5, and P6 are as follows: year 5, 5, 3, 5, 5, and 4, respectively. Differences in scores between DFT baseline and latest time point that exceed MIDs are illustrated with a delta symbol (Δ) followed by the value of the difference. Dotted line indicates general US population average. (B) Individual and mean WPAI-CIQ overall activity impairment because of health scores over time, with lower scores indicating less impairment because of health. n values for DFT baseline, Ext Scr and years 1, 2, 3, 4, and 5 are as follows: 6, 6, 6, 6, 6, 5, and 4, respectively. (C) Individual and mean patient general assessment scores are shown with lower scores indicating a reduction in disease activity. n values for DFT baseline, Ext Scr and years 1, 2, 3, 4, and 5 are as follows: 6, 6, 6, 6, 6, 5, and 4, respectively. (D) Individual and mean physician general assessment scores are shown with lower scores indicating a reduction in disease activity. There were no values reported for Ext Scr. n values for DFT baseline and years 1, 2, 3, 4, and 5 are as follows: 6, 1, 6, 6, 5, and 4, respectively. Error bars are standard error of the mean. BP, bodily pain; Ext Scr, extension screening; GH, general health; MCS, mental component score; MH, mental health; MID, minimally important difference; PCS, physical component score; PF, physical functioning; PGA, physician general assessment; PtGA, patient general assessment; RE, role (emotional); RP, role (physical); SF-36, Short-Form Health Survey 36; SF, social functioning; VT, vitality; WPAI-CIQ, Work Productivity and Activity Impairment Questionnaire plus Classroom Impairment Questionnaire.