Relevant HSPGs, HS-related genes, and HS-modification signatures in various hematopoietic cell lineages. (A) Sunburst plot of known functionally relevant HS-related genes within specific hematopoietic lineages. The specific HS-related gene or protein for which expression or function has been identified (outer circle) within the categories of HS-related genes, including HSPGs and HS synthesis enzymes (Synth.), and HS-modification enzymes (Mod.) (middle circle), are listed for each hematopoietic cell type (inner circle). (B) Sunburst plot of HS modifications identified as functionally relevant for each hematopoietic cell type. For each hematopoietic cell type (inner circle), the specific modification and residue (outer circle) among the possible types of modifications, including epimerization (Epi), N-sulfation (N-Sulf), and O-sulfation (O-Sulf) (middle circle) is listed.