Treatment with combination of Aza or At with pegIFN-α. (A) Schematic drawing of the experimental setup for BM transplantations and treatment. (B) Time course of changes in body weight (%); n = 6-8 per group. (C) Spleen weight at terminal workup after 12 weeks of treatment (n = 5-8 mice per group). (D) Liver weight at terminal workup (n = 5-8 mice per group). (E) Time course of blood counts and GFP chimerism of recipient mice (n = 6-8 mice per group). (F) Frequencies and GFP chimerism of HSCs (LT-HSCs) in BM and spleen at terminal workup after 12 weeks of treatment (n = 5-8 mice per group). ANOVA with subsequent Tukey posttest was used. ∗P < .05; ∗∗P < .01; ∗∗∗P < .001; ∗∗∗∗P < .0001.