Severe disease-related events. Cumulative incidence and incidence per patient-year for severe disease-related events: any severe event (A-B), severe bleeding (C-D), severe infection (E-F), autoimmunity (G-H), and malignancy (I,J). Follow-up censored at the time of first procedure. Only the first event of a category was counted for cumulative incidence, whereas all events of a specific category were counted for incidence per year.