Study design. The risk of VTE was assessed by generating independent Firth logistic regression models in data sets from the FinnGen project (N = 454 149 participants) and the UKB (N = 484 206 participants). The results were then combined using a random-effects meta-analysis (N = 938 255). The number of VTE cases and the genotype breakdown of the participants at each stage were noted. hom, homozygous; het, heterozygous.