Association of NBN variants with clinical characteristics of B-ALL. (A) Characteristics of B-ALL in carriers of an experimentally validated nonfunctional germ line NBN variant (n = 16) were compared with those with WT NBN status (n = 3719) treated in COG P9900, AALL0232, St. Jude Total XIIIB and St. Jude Total XV clinical trials. (B) Event-free survival and (C) overall survival in carriers of an experimentally validated nonfunctional germ line NBN variant and patients with WT NBN status.