Odds ratios (ORs) of overall VTE and unprovoked VTE as a function of miR-145 plasma expression levels in a generalized additive regression model. (A) Overall VTE; (B) unprovoked VTE. ORs were adjusted for age, sex, BMI, and cancer and arterial CVD at baseline. The solid lines depict ORs surrounded by shaded areas (gray) showing 95% CIs. The distributions of miR-145 plasma levels are shown as density plots (light gray) at the bottom, and white vertical lines indicate quartile cutoffs.