Predictors of unsustained MRD negativity. (A) Probability of unsustained MRD negativity in patients with amplification (amp)(1q) and gain(1q) and without 1q abnormalities. (B) Probability of unsustained MRD negativity in patients with 0, 1, and ≥2 concomitant HRCAs. (C) Probability of unsustained MRD negativity in patients with CTCs ≤0.07% vs >0.07%. (D) Probability of unsustained MRD negativity in patients who reached first MRD negativity preconsolidation (Pre-Cons) and postconsolidation (Post-Cons). HRCA defined as gain/amp of chromosome 1q (1q+) and/or t(4;14) and/or t(14;16) and/or del(17p) detected by fluorescence in situ hybridization.