MRD resurgence and/or PD in patients (Pts) achieving undetectable MRD. (A) Cumulative incidence of MRD resurgence and PD events at the time of median follow-up (73 months from MRD negativity). (B) Median progression-free survival in patients with an MRD resurgence event. (C) Swimmer plots landmarked at the time of MRD-negative achievement, with subsequent MRD assessments and time to relapse or last follow-up. Patients with sustained MRD negativity before MRD resurgence (defined as MRD negative confirmed 1 year apart) are marked with an S. Patients having PD without previous MRD resurgence are represented in supplemental Figure 4. R, randomization.