Many treatments across several treatment categories are used in the treatment of iMCD. (A) Patients with iMCD receive a variety of treatments, including corticosteroids (91%), immunomodulators (68%), antineoplastic agents (30%), and anti-IL6–directed therapy (85%). (B) Forty-one unique drugs have been administered across a cohort of 102 patients with iMCD, and siltuximab, the first-line recommended therapy, has been administered to 65% of this cohort as part of various regimens.