Figure 2.
Correlation between monosomy 16p and high risk events. (A-B) The CN of BCMA and TP53 within each patient across various genomic platforms, assessed using bulk genomic data. Log ratio of sequencing coverage is shown on the left and middle panels for WGS data sets. Smooth copy number estimated from the SNP array is used on the right panels. Top panels show BCMA and TP53 locus (A) for each patient (a dot in the scatter plot) in 3 data sets, and bottom panels (B) show BCMA and CDKN2C loci. Spearman rank correlation ρ for samples in the bottom left corner box (samples in which both genes are deleted) is 0.65 (P value = 6.27e–06) for the WGS data sets and 0.53 (P value = 2.6e–05) for SNP array in the top panels and 0.67 (P = 8.67 e−08) and 0.65 (P = 7.8e–07) in the bottom panels, respectively. (C) CN estimates of the single cells (each row in panels) for 2 patients (right and left panels). Clusters or single cells are shown with histograms on the right of each panel. Genomic regions from the beginning of the chromosome 16p arm to the end of the chromosome 17 q arm are shown on the x-axis. The coverage and data quality are shown in the bottom panels. The co-occurrences of CN events are shown in the bottom tables for each patient. Vertical gray lines are used to mark BCMA and TP53 locations. (D) (Top) Graphs showing the co-occurrence of deletions (blue) and gains (red) of CNAs at the single-cell level in a relapsed patient. Each column is a cell. (Bottom) Table showing the co-occurrence of deletions and duplications of BCMA and TP53.

Correlation between monosomy 16p and high risk events. (A-B) The CN of BCMA and TP53 within each patient across various genomic platforms, assessed using bulk genomic data. Log ratio of sequencing coverage is shown on the left and middle panels for WGS data sets. Smooth copy number estimated from the SNP array is used on the right panels. Top panels show BCMA and TP53 locus (A) for each patient (a dot in the scatter plot) in 3 data sets, and bottom panels (B) show BCMA and CDKN2C loci. Spearman rank correlation ρ for samples in the bottom left corner box (samples in which both genes are deleted) is 0.65 (P value = 6.27e–06) for the WGS data sets and 0.53 (P value = 2.6e–05) for SNP array in the top panels and 0.67 (P = 8.67 e−08) and 0.65 (P = 7.8e–07) in the bottom panels, respectively. (C) CN estimates of the single cells (each row in panels) for 2 patients (right and left panels). Clusters or single cells are shown with histograms on the right of each panel. Genomic regions from the beginning of the chromosome 16p arm to the end of the chromosome 17 q arm are shown on the x-axis. The coverage and data quality are shown in the bottom panels. The co-occurrences of CN events are shown in the bottom tables for each patient. Vertical gray lines are used to mark BCMA and TP53 locations. (D) (Top) Graphs showing the co-occurrence of deletions (blue) and gains (red) of CNAs at the single-cell level in a relapsed patient. Each column is a cell. (Bottom) Table showing the co-occurrence of deletions and duplications of BCMA and TP53.

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