Correlation plot showing the likelihood of co-occurrence of gene mutations in the same patient. The association between gene mutations is based on the compilation of data from 5 published cohorts comprising a total of 3002 MPN patients, including 1497 ET, 535 PV, and 970 PMF or secondary MF patients.^16,17,79,80 The color code and numbers on the y-axis represent the Pearson R-coefficient, which indicates the strength of positive or negative associations between 2 gene mutations. Only the significant associations are depicted (P-value < .01).