FXII(a) inhibition attenuates femoral vein thrombosis induced by electrolytic injury. Townes HbAA and HbSS mice were treated with IgG or 15D10 (5 mg/kg, IV) 30 minutes before electrolytic injury to the femoral vein. Quantification of (A) relative fibrin intensity over time and (B) the total fibrin fluorescence measured by AUC. Quantification of (C) relative platelet intensity over time and (D) the total platelet fluorescence measured by AUC. Data represent mean ± SEM; n = 6 to 10 mice per group. (E) Representative images of fibrin (red) and platelet (green) accumulation taken 45 minutes after electrolytic injury. (F) Histomorphometric quantification of clot volume. Data represent mean ± SEM of clot volume (mm³); n = 6 to 10 mice per group. ∗P < .05, ∗∗P < .01, ∗∗∗P < .001 by two-way ANOVA and Tukey post-hoc test. ANOVA, analysis of variance; AUC, area under the curve.