Families with putative germ line variants. (A) Study overview and prioritization schema. (B) Counts of coding variants according to prioritization category overall and per pedigree. (C) Heat map of coding variants showing the number of carriers across pedigrees, the ClinVar rating, the variant classification based on American College of Medical Genetics and Genomics (ACMG)/Association for Molecular Pathology (AMP) guidelines, and taking into account evidence of familial segregation and a possible predisposition to HL and the priority level based on our prioritization schema as described in Panel A. (D) Counts of noncoding variants according to prioritization category overall and per pedigree. (E) Heat map of noncoding variants showing recurrence across pedigrees. ncRNA, noncoding RNA; ∗pedigrees with early-onset; † the variant is within 1 logarithm of the odds (1-LOD) multipoint logarithm of the odds (MLOD) region.