Reconstitution of cellular immunity. (A) Infection scores before and after GT (scoring includes events during the last year of F/U; median, 7.6 years; range, 5.3-8.8 years). (B) Eczema score before and after GT (scoring includes events during the last year of F/U; median, 7.6 years; range, 5.3-8.8 years). (C) Reconstitution of T cells after GT (left: absolute values; right: relative to baseline). (D) Comparison of CD4⁺:CD8⁺ T-cell ratio before and after GT (at latest F/U). (E) Comparison of percentage of naive CD8⁺ T cells (at latest F/U). (F) Evaluation of T-cell proliferation in response to anti-CD3 by thymidine incorporation assay (at 2-3 years after GT) and (G) by carboxyfluorescein succinimidyl ester proliferation assay (at 2 years after GT), data not available for patient 5. The shaded area represents the median with interquartile ranges of healthy controls (n = 21). (H) Deep sequencing of TCR repertoire (patient 1, 2 years after GT; patient 2, 1 year after GT; patient 3, 1 year after GT). The frequency of the top 100 most abundant unique clonotypes is expressed as a percentage of the total number of sequences obtained. F/U, follow-up; HC, healthy control; ULN, upper limit of normal; Y, year.