Profile of IDH mutations in AML according to age and cooccurring mutations. (A) IDH mutation prevalence increases with age shown as IDH1, IDH2, and combined IDH1/IDH2 in study-defined age groups. (B) The cooccurring mutational profile of IDH^mut AML varies from that of IDH^WT AML. CBF, core-binding factor; KMT2A-R, KMT2A-rearranged; NK, normal karyotype; ns, nonsignificant; PTD, partial tandem duplication; TKD, tyrosine kinase domain.