Demographics and clinical presentation (A) and swimmer plot of treatment and outcome (B) in the 21 patients included in the study. AntiTNF, anti–tumor necrosis factor; CNS, central nervous system; CR, complete response; INF-α, interferon-alfa; mTORi, mammalian target of rapamycin inhibitor; PD, progressive disease; PR, partial response; RT, radiotherapy; SD, stable disease.