Sinusoidal endothelial cells show higher Fgf23 expression than other BM stromal cell populations in mice with normal iron balance. Visualization of scRNA-Seq data from 20 896 nonhematopoietic cells (mixed bone and BM fractions) generated by Baryawno et al.45 Data were downloaded from the Broad Institute Single Cell Portal (https://singlecell.broadinstitute.org/single_cell/study/SCP361/mouse-bone-marrow-stroma-in-homeostasis). T-distributed stochastic neighbor embedding (tSNE) plots (A) highlighting the 5 cell clusters of interest and (B) showing the Fgf23 expression. (C) The expression of selected genes is shown for each individual cell within the 5 cell clusters highlighted in A. TP10K transcripts per 10 thousand transcripts. EC, endothelial cell; OLC, osteolineage cell.
