Figure 2.
Heterozygous Fgf23 disruption does not alter iron homeostasis in mice with 2, 1, or 0 wild-type Tmprss6 alleles. Shown for 8-week-old male mice of different Tmprss6-Fgf23 genotype combinations are (A) serum hepcidin, (B) serum iron, (C) Hgb, (D) MCV, (E) MCH, (F) liver nonheme iron concentration, (G) heart nonheme iron concentration, (H) kidney nonheme iron concentration, (I) spleen-to-body-weight ratio, and (J) total spleen nonheme iron content. n = 4 to 7 per group. Two-way ANOVA revealed significant effects of the Tmprss6 genotype on all parameters (P < .001), whereas no significant effect of the Fgf23 genotype on any parameter was detected. For all bar graphs, data represent the mean ± standard deviation. ∗P < .05; ∗∗P < .01; ∗∗∗P < .001; and ∗∗∗∗P < .0001 using two-way ANOVA with Tukey post hoc test. G, eGFP allele.

Heterozygous Fgf23 disruption does not alter iron homeostasis in mice with 2, 1, or 0 wild-type Tmprss6 alleles. Shown for 8-week-old male mice of different Tmprss6-Fgf23 genotype combinations are (A) serum hepcidin, (B) serum iron, (C) Hgb, (D) MCV, (E) MCH, (F) liver nonheme iron concentration, (G) heart nonheme iron concentration, (H) kidney nonheme iron concentration, (I) spleen-to-body-weight ratio, and (J) total spleen nonheme iron content. n = 4 to 7 per group. Two-way ANOVA revealed significant effects of the Tmprss6 genotype on all parameters (P < .001), whereas no significant effect of the Fgf23 genotype on any parameter was detected. For all bar graphs, data represent the mean ± standard deviation. ∗P < .05; ∗∗P < .01; ∗∗∗P < .001; and ∗∗∗∗P < .0001 using two-way ANOVA with Tukey post hoc test. G, eGFP allele.

This Feature Is Available To Subscribers Only

or Create an Account

Close Modal
Close Modal