Anti-AdV T-cell activity and clinical response in patients treated with AdV-specific VSTs for active adenovirus (AdV) infection. (A) Anti-adenoviral antigen (hexon, penton) T-cell response of the AdV-specific VST products as detected by IFN-γ ELISpot assay. Anti-AdV antigen T-cell response and AdV viral load (copies per milliliter) in the recipient PB post-VST infusion for patient P3, P11 treated with AdV infection (B and C) and timing of concomitant standard antiviral treatment. PCR, polymerase chain reaction; SFU, spot forming units.