Laboratory measurements during the trial. The data points represent the estimated means based on a mixed-model repeated-measures analysis after adjustment for the baseline value. The vertical bars denote 95% CIs. The dependent variable was the laboratory value at each predetermined time point. Fixed effects included the interaction between treatment and time. Time was treated as a categorical variable. The subject was included in the model as a random effect. A first-order autoregressive covariance matrix was used to model the within-patient variance-covariance errors. Prespecified secondary outcomes were laboratory measures of (A) hemoglobin, (B) hematocrit, (C) zinc protoporphyrin, (D) reticulocyte hemoglobin, (E) ferritin, (F) soluble transferrin receptor, (G) transferrin saturation, and (H) hepcidin. PTR, posttransfusion recovery.