Effects of rondoraptivon pegol on VWF parameters. Rondoraptivon pegol increases plasma levels of VWF–GpIbM (%), ristocetin cofactor (VWF:RCo) (%), and collagen binding activity (VWF:CB) (%) in patients with type 2B VWD. The dotted line represents the nonthrombocytopenic patient, and the horizontal dashed line is the lower normal limit. Note logarithmic scale of y axis.