Index cases and affected family members have a comparable desmopressin response. Each line represents a single patient. All family members are illustrated with the same color. Index patients are indicated with dots. (A) Desmopressine response in index cases and affected family members with type 1 VWD. –Type 1 patients without a VWF gene variant. +Type 1 patients with a VWF gene variant. (B) Desmopressine response in index cases and affected family members with type 2 VWD.