The balanced supply of stimulatory and inhibitory angiocrine factors choreograph the self-renewal and differentiation of HSCs and HSPCs. Secretion of ANGPTL2 specifically by vascular niche endothelial cells within the hematopoietic microenvironment supports the maintenance of HSCs and recovery from myeloablation. ANGPTL2, through interaction with leukocyte immunoglobulin-like receptor B2 (LILRB2) expressed on HSCs, switches on the expression of PPARD and G0s2, thereby dictating the homeostatic equilibrium of HSCs. G-CSF, granulocyte colony-stimulating factor; GM-CSF, granulocyte-macrophage colony-stimulating factor; IL-7, interleukin 7; M-CSF, macrophage colony-stimulating factor; TGF β, transforming growth factor β; TNF, tumor necrosis factor.

The balanced supply of stimulatory and inhibitory angiocrine factors choreograph the self-renewal and differentiation of HSCs and HSPCs. Secretion of ANGPTL2 specifically by vascular niche endothelial cells within the hematopoietic microenvironment supports the maintenance of HSCs and recovery from myeloablation. ANGPTL2, through interaction with leukocyte immunoglobulin-like receptor B2 (LILRB2) expressed on HSCs, switches on the expression of PPARD and G0s2, thereby dictating the homeostatic equilibrium of HSCs. G-CSF, granulocyte colony-stimulating factor; GM-CSF, granulocyte-macrophage colony-stimulating factor; IL-7, interleukin 7; M-CSF, macrophage colony-stimulating factor; TGF β, transforming growth factor β; TNF, tumor necrosis factor.

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