Immune modulation of BM T cells during lenalidomide maintenance. (A) UMAP of BM lymphocytes from patients with active MM (n = 40). (B) Phylogenetic tree and hierarchical clustering of unique subpopulations within CD4, CD8, and γδ T cells. (C) Pie chart diagrams showing the distribution of T-cell subsets significantly altered from the pre-maintenance time point to the second year of maintenance within CD4⁺, CD8⁺, and γδ T cells. (D) Spider plots displaying the kinetics of T-cell subsets that were significantly different between patients treated with Rd and these 2 drugs plus ixazomib (IRd). M1, 1st year of maintenance; M2, 2nd year of maintenance; PC, post-consolidation; TEMRA, T-cell effector memory CD45RA⁺.