Effects of BCR stimulation on transwell migration in isogenic lymphoma cells expressing or not expressing HGAL. (A) Schematic presentation of BCR downstream cascade regulating cytoskeleton and cell motility. Question mark represents contradictory data in the literature on the potential of PI3K to activate BTK. (B) Effects of BCR activation with and without SDF1 stimulation on transwell migration of isogenic U2932 and TMD8 lymphoma cells expressing or not expressing HGAL. (C) Effects of BCR activation with and without SDF1 stimulations on transwell migration of isogenic wild-type BJAB cells expressing HGAL and HGAL KO cells. (D) Effect of constitutively active RhoA (Q63L) expression on transwell migration of Raji cells. *P < .05; **P < .01; ***P < .001; ****P < .0001.