Adjusted mean differences in physical and mental health-related domains by the SF-36 questionnaire between patients with APL previously treated with ATRA-ATO vs ATRA chemotherapy. The figure represents the differences in mean scores and corresponding 95% CIs, adjusted for time since protocol completion, of physical (A) and mental health-related scales (B) from the SF-36 questionnaire between long-term APL survivors previously treated with ATRA plus arsenic trioxide or ATRA plus chemotherapy. A positive difference in all scales indicates better outcomes in the ATRA plus arsenic trioxide arm than in the ATRA plus chemotherapy arm. A red circle indicates a clinically relevant difference.