Simplified depiction of BCR, PI3K, and NF-κB signaling in DLBCL. Activation of the BCR induces a signaling cascade that culminates in the activation of the NF-κB, PI3K/mTOR, MAPK, and NFAT pathways. Other key survival pathways in DLBCL are depicted. Constitutive MYD88 signaling also induces activation of the NF-κB pathway. Genetic aberrations are indicated by colored asterisks.