PTPN11 mutations and associated comutations. (A) Schematic illustration showing the position of acquired PTPN11 mutations in 106 AML patients and the domain structure of PTPN11: 2 Src homology 2 domains (N-SH2 and C-SH2) and a PTP (protein tyrosine phosphatase) domain. Recurrent alterations and their frequency in AML patients are indicated for PTPN11 exons 3 and 13. (B) PTPN11 VAFs, number of comutations (coded by color), PTPN11 clonal rank (dominant vs subclonal), affected functional domains (N-SH2 vs PTP), and the number of PTPN11 single (sm) or double mutated (dm) patients. (C) Associated comutations in PTPN11-mut patients.