Figure 7.
Sketch representing the molecular mechanism beneath Duv and Ven synergism. Molecular pathways activating PI3K-δ/γ signaling (Akt and GSK3β phosphorylation). Following duvelisib treatment, PI3K signaling is inhibited resulting in Mcl-1 and c-Myc ubiquitination and degradation. The simultaneous inhibition of Bcl-2 further sustains RS cell apoptosis.