Undetectable MRD overcomes the dismal survival of patients with MM with high-risk CAs. Impact on PFS (A) and OS (B), according to MRD status in patients with standard- and high-risk CAs. (C) Patients with del(17p13) are listed according to the percentage of tumor cells having each CA (from lower to higher), MRD status at the latest evaluation time point, and outcome. OS is represented by gray bars, and progression and deaths are identified by orange and purple boxes, respectively. P values were determined by the 2-sided log-rank test.