Biomarker combinations

Biomarker combinationSensitivity,%Specificity,%Positive predictive value, %Negative predictive value, %
A* αβ-DNTs and in vitro apoptosis assay 79.3 93.7 85.2 90.8 
B† In vitro apoptosis assay and sFASL 76.9 92 83.3 88.5 
Biomarker combinationSensitivity,%Specificity,%Positive predictive value, %Negative predictive value, %
A* αβ-DNTs and in vitro apoptosis assay 79.3 93.7 85.2 90.8 
B† In vitro apoptosis assay and sFASL 76.9 92 83.3 88.5 
*

Combination of elevated αβ-DNTs and abnormal in vitro apoptosis assay was the most sensitive and specific biomarker combination to distinguish between definite and unlikely ALPS.

†

Combination of elevated in vitro apoptosis assay and sFASL were the most predictive of underlying FAS mutation.

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