Factors prognostic of PFS, OS, and ORR on multivariable analysis
| Prognostic factors . | PFS . | OS . | ORR . | |||
|---|---|---|---|---|---|---|
| HR (95% CI) . | P . | HR (95% CI) . | P . | OR (95% CI) . | P . | |
| Elevated LDH | 1.7 (1.2-2.7) | .009 | 2.1 (1.4-3.2) | <.001 | 0.3 (0.2-0.6) | <.001 |
| Transformed | 0.9 (0.6-1.3) | .5 | 0.8 (0.5-1.1) | .2 | 1.2 (0.6-2.5) | .6 |
| Bulk >10cm | 1.8 (1.2-2.9) | .01 | 1.7 (1.1-2.7) | .03 | — | — |
| >1 EN site | 1.2 (0.8-1.8) | .3 | 1.6 (1.1-2.3) | .02 | 0.6 (0.3-1.2) | .1 |
| ECOG >1 | 2.1 (1.2-3.7) | .01 | 1.7 (1.0-3.1) | .06 | — | — |
| BM positive | 0.7 (0.3-1.6) | .4 | — | — | — | — |
| Refractory | 1.4 (0.9-2.3) | .1 | 1.5 (1.0-2.3) | .07 | 0.6 (0.3-1.2) | .1 |
| CAR T | Ref | Ref | Ref | |||
| Alternate | 1.1 (0.7-1.8) | .7 | 1.3 (0.8-2.1) | .2 | 0.2 (0.1-0.4) | <.001 |
| Prognostic factors . | PFS . | OS . | ORR . | |||
|---|---|---|---|---|---|---|
| HR (95% CI) . | P . | HR (95% CI) . | P . | OR (95% CI) . | P . | |
| Elevated LDH | 1.7 (1.2-2.7) | .009 | 2.1 (1.4-3.2) | <.001 | 0.3 (0.2-0.6) | <.001 |
| Transformed | 0.9 (0.6-1.3) | .5 | 0.8 (0.5-1.1) | .2 | 1.2 (0.6-2.5) | .6 |
| Bulk >10cm | 1.8 (1.2-2.9) | .01 | 1.7 (1.1-2.7) | .03 | — | — |
| >1 EN site | 1.2 (0.8-1.8) | .3 | 1.6 (1.1-2.3) | .02 | 0.6 (0.3-1.2) | .1 |
| ECOG >1 | 2.1 (1.2-3.7) | .01 | 1.7 (1.0-3.1) | .06 | — | — |
| BM positive | 0.7 (0.3-1.6) | .4 | — | — | — | — |
| Refractory | 1.4 (0.9-2.3) | .1 | 1.5 (1.0-2.3) | .07 | 0.6 (0.3-1.2) | .1 |
| CAR T | Ref | Ref | Ref | |||
| Alternate | 1.1 (0.7-1.8) | .7 | 1.3 (0.8-2.1) | .2 | 0.2 (0.1-0.4) | <.001 |
P values in bold are statistically significant. Dashes indicate analysis was not performed on these factors as they were not significant in the univariable analysis.
EN, extranodal; HR, hazard ratio; LDH, lactate dehydrogenase.