Table 3.

Univariate analysis

3-y OS (95% CI)3-y EFS (95% CI)3-y GF (95% CI)Grade III-IV aGVHD (95% CI)cGVHD (95% CI)
Age      
 <18 y 0.86 (0.83-0.89) 0.76 (0.72-0.8) 0.13 (0.10-0.16) 0.08 (0.06-0.11) 0.17 (0.13-0.20) 
 ≥18 y 0.76 (0.66-0.86) 0.69 (0.57 0.8) 0.12 (0.04-0.21) 0.10 (0.03-0.1) 0.22 (0.11-0.33) 
 P .009 .2 .74 066 .40 
Genetics      
 AR 0.86 (0.80-0.93) 0.77 (0.69-0.85) 0.11 (0.05-0.17) 0.09 (0.03-0.15) 0.14 (0.07-0.22) 
 X-linked 0.85 (0.81-0.89) 0.75 (0.70-0.80) 0.14 (0.10-0.18) 0.08 (0.05-0.11) 0.15 (0.11-0.20) 
 P .9 .7 .39 .66 .65 
Colitis      
 Present 0.78 (0.70-0.86) 0.72 (0.63-0.81) 0.09 (0.03-0.14) 0.11 (0.05-0.17) 0.18 (0.10-0.26) 
 Absent 0.87 (0.84-0.91) 0.76 (0.71-0.8) 0.15 (0.11-0.19) 0.08 (0.05-0.11) 0.14 (0.10-0.18) 
 P .01 .5 .08 .33 .31 
Liver derangement      
 Present 0.90 (0.80-0.99) 0.89 (0.79-0.99) 0.05 (0-0.13) 0.05 (0-0.11) 0.13 (0.01-0.26) 
 Absent 0.84 (0.81-0.88) 0.74 (0.69-0.78) 0.14 (0.10-0.17) 0.08 (0.06-0.11) 0.16 (0.12-0.19) 
 P .4 .04 .11 .38 .52 
Renal derangement      
 Present 0.76 (0.59-0.92) 0.75 (0.57-0.92) 0.16 (0.01-0.31) 0.08 (0-0.19) 0.17 (0.01-0.33) 
 Absent 0.85 (0.81-0.88) 0.74 (0.7-0.79) 0.14 (0.10-0.17) 0.08 (0.05-0.10) 0.15 (0.11-0.19) 
 P .1 .8 .62 .99 .76 
Infections      
 Present 0.83 (0.79-0.88) 0.74 (0.69-0.79) 0.13 (0.09-0.17) 0.08 (0.05-0.12) 0.14 (0.10-0.18) 
 Absent 0.87 (0.81-0.92) 0.74 (0.67-0.81) 0.14 (0.08-0.20) 0.06 (0.02-0.10) 0.16 (0.10-0.23) 
 P .4 .9 .65 .32 .62 
Conditioning regimen      
 Bu/cy 0.88 (0.82-0.94) 0.84 (0.77-0.91) 0.03 (0.001-0.07) 0.11 (0.05-0.17) 0.13 (0.07-0.20) 
 Bu/flu 0.84 (0.79-0.88) 0.75 (0.7-0.8) 0.13 (0.09-0.17) 0.07 (0.04-0.09) 0.20 (0.15-0.26) 
 Treo/flu 0.90 (0.82-0.98) 0.71 (0.59-0.83) 0.22 (0.11-0.33) 0.06 (0.01-0.12) 0.09 (0.02-0.15) 
 Treo/flu/TT 0.95 (0.89-1) 0.85 (0.74-0.95) 0.10 (0.01-0.19) 0.09 (0.01-0.16) 0.07 (0-0.16) 
 P .09 .1 .009 .38 .04 
In vivo T-cell depletion      
 ATG 0.91 (0.85-0.97) 0.84 (0.76-0.93) 0.09 (0.02-0.16) 0.05 (0.01-0.10) 0.18 (0.09-0.27) 
 Alemtuzumab 0.92 (0.81-1) 0.88 (0.76-1) 0.07 (0-0.18) 0.03 (0-0.09) 0.04 (0-0.12) 
 None 0.86 (0.80-0.93) 0.84 (0.77-0.91) 0.02 (0-0.06) 0.15 (0.08-0.22) 0.16 (0.08-0.24) 
 P .4 .8 .25 .02 .22 
Donor type      
 MFD 0.89 (0.85-0.93) 0.85 (0.80-0.90) 0.05 (0.02-0.08) 0.09 (0.05-0.13) 0.15 (0.10-0.21) 
 MUD 0.87 (0.83-0.91) 0.74 (0.69-0.79) 0.14 (0.10-0.19) 0.08 (0.04-0.11) 0.15 (0.11-0.20) 
 1-Ag MM 0.76 (0.67-0.85) 0.66 (0.55-0.76) 0.18 (0.09-0.26) 0.13 (0.06-0.19) 0.23 (0.14-0.33) 
 >1-Ag MM 0.79 (0.63-0.95) 0.62 (0.42-0.82) 0.24 (0.07-0.42) 0.03 (0-0.10) 0.32 (0.05-0.60) 
 P .02 <.001 <.001 .36 .24 
Stem cell source      
 PB 0.87 (0.7-0.87) 0.7 (0.63-0.77) 0.15 (0.10-0.21) 0.07 (0.03-0.11) 0.18 (0.12-0.25) 
 BM 0.88 (0.85-0.91) 0.78 (0.74-0.83) 0.11 (0.08-0.14) 0.09 (0.06-0.11) 0.17 (0.13-0.21) 
 CB 0.82 (0.67-0.96) 0.62 (0.44-0.8) 0.27 (0.11 0.44) 0.14 (0.01-0.27) 0.17 (0.01-0.33) 
 P .2 .006 .009 .48 .92 
Year of HCT      
 <2013 0.86 (0.83-0.90) 0.77 (0.73-0.82) 0.11 (0.08-0.15) 0.09 (0.06-0.12) 0.19 (0.14-0.24) 
 ≥2013 0.83 (0.79-0.88) 0.73 (0.67-0.78) 0.15 (0.10-0.19) 0.08 (0.05-0.11) 0.14 (0.10-0.19) 
 P .4 .3 .299 .63 .33 
3-y OS (95% CI)3-y EFS (95% CI)3-y GF (95% CI)Grade III-IV aGVHD (95% CI)cGVHD (95% CI)
Age      
 <18 y 0.86 (0.83-0.89) 0.76 (0.72-0.8) 0.13 (0.10-0.16) 0.08 (0.06-0.11) 0.17 (0.13-0.20) 
 ≥18 y 0.76 (0.66-0.86) 0.69 (0.57 0.8) 0.12 (0.04-0.21) 0.10 (0.03-0.1) 0.22 (0.11-0.33) 
 P .009 .2 .74 066 .40 
Genetics      
 AR 0.86 (0.80-0.93) 0.77 (0.69-0.85) 0.11 (0.05-0.17) 0.09 (0.03-0.15) 0.14 (0.07-0.22) 
 X-linked 0.85 (0.81-0.89) 0.75 (0.70-0.80) 0.14 (0.10-0.18) 0.08 (0.05-0.11) 0.15 (0.11-0.20) 
 P .9 .7 .39 .66 .65 
Colitis      
 Present 0.78 (0.70-0.86) 0.72 (0.63-0.81) 0.09 (0.03-0.14) 0.11 (0.05-0.17) 0.18 (0.10-0.26) 
 Absent 0.87 (0.84-0.91) 0.76 (0.71-0.8) 0.15 (0.11-0.19) 0.08 (0.05-0.11) 0.14 (0.10-0.18) 
 P .01 .5 .08 .33 .31 
Liver derangement      
 Present 0.90 (0.80-0.99) 0.89 (0.79-0.99) 0.05 (0-0.13) 0.05 (0-0.11) 0.13 (0.01-0.26) 
 Absent 0.84 (0.81-0.88) 0.74 (0.69-0.78) 0.14 (0.10-0.17) 0.08 (0.06-0.11) 0.16 (0.12-0.19) 
 P .4 .04 .11 .38 .52 
Renal derangement      
 Present 0.76 (0.59-0.92) 0.75 (0.57-0.92) 0.16 (0.01-0.31) 0.08 (0-0.19) 0.17 (0.01-0.33) 
 Absent 0.85 (0.81-0.88) 0.74 (0.7-0.79) 0.14 (0.10-0.17) 0.08 (0.05-0.10) 0.15 (0.11-0.19) 
 P .1 .8 .62 .99 .76 
Infections      
 Present 0.83 (0.79-0.88) 0.74 (0.69-0.79) 0.13 (0.09-0.17) 0.08 (0.05-0.12) 0.14 (0.10-0.18) 
 Absent 0.87 (0.81-0.92) 0.74 (0.67-0.81) 0.14 (0.08-0.20) 0.06 (0.02-0.10) 0.16 (0.10-0.23) 
 P .4 .9 .65 .32 .62 
Conditioning regimen      
 Bu/cy 0.88 (0.82-0.94) 0.84 (0.77-0.91) 0.03 (0.001-0.07) 0.11 (0.05-0.17) 0.13 (0.07-0.20) 
 Bu/flu 0.84 (0.79-0.88) 0.75 (0.7-0.8) 0.13 (0.09-0.17) 0.07 (0.04-0.09) 0.20 (0.15-0.26) 
 Treo/flu 0.90 (0.82-0.98) 0.71 (0.59-0.83) 0.22 (0.11-0.33) 0.06 (0.01-0.12) 0.09 (0.02-0.15) 
 Treo/flu/TT 0.95 (0.89-1) 0.85 (0.74-0.95) 0.10 (0.01-0.19) 0.09 (0.01-0.16) 0.07 (0-0.16) 
 P .09 .1 .009 .38 .04 
In vivo T-cell depletion      
 ATG 0.91 (0.85-0.97) 0.84 (0.76-0.93) 0.09 (0.02-0.16) 0.05 (0.01-0.10) 0.18 (0.09-0.27) 
 Alemtuzumab 0.92 (0.81-1) 0.88 (0.76-1) 0.07 (0-0.18) 0.03 (0-0.09) 0.04 (0-0.12) 
 None 0.86 (0.80-0.93) 0.84 (0.77-0.91) 0.02 (0-0.06) 0.15 (0.08-0.22) 0.16 (0.08-0.24) 
 P .4 .8 .25 .02 .22 
Donor type      
 MFD 0.89 (0.85-0.93) 0.85 (0.80-0.90) 0.05 (0.02-0.08) 0.09 (0.05-0.13) 0.15 (0.10-0.21) 
 MUD 0.87 (0.83-0.91) 0.74 (0.69-0.79) 0.14 (0.10-0.19) 0.08 (0.04-0.11) 0.15 (0.11-0.20) 
 1-Ag MM 0.76 (0.67-0.85) 0.66 (0.55-0.76) 0.18 (0.09-0.26) 0.13 (0.06-0.19) 0.23 (0.14-0.33) 
 >1-Ag MM 0.79 (0.63-0.95) 0.62 (0.42-0.82) 0.24 (0.07-0.42) 0.03 (0-0.10) 0.32 (0.05-0.60) 
 P .02 <.001 <.001 .36 .24 
Stem cell source      
 PB 0.87 (0.7-0.87) 0.7 (0.63-0.77) 0.15 (0.10-0.21) 0.07 (0.03-0.11) 0.18 (0.12-0.25) 
 BM 0.88 (0.85-0.91) 0.78 (0.74-0.83) 0.11 (0.08-0.14) 0.09 (0.06-0.11) 0.17 (0.13-0.21) 
 CB 0.82 (0.67-0.96) 0.62 (0.44-0.8) 0.27 (0.11 0.44) 0.14 (0.01-0.27) 0.17 (0.01-0.33) 
 P .2 .006 .009 .48 .92 
Year of HCT      
 <2013 0.86 (0.83-0.90) 0.77 (0.73-0.82) 0.11 (0.08-0.15) 0.09 (0.06-0.12) 0.19 (0.14-0.24) 
 ≥2013 0.83 (0.79-0.88) 0.73 (0.67-0.78) 0.15 (0.10-0.19) 0.08 (0.05-0.11) 0.14 (0.10-0.19) 
 P .4 .3 .299 .63 .33 

Results are highlighted in bold according to the definition of significance being P ≤ .05.

1-Ag MM, 1-antigen-mismatched donor; BM, bone marrow; Bu, busulfan; CB, cord blood; Cy, cyclophosphamide; Flu, fludarabine; PB, peripheral blood; Treo, treosulfan; TT, thiotepa.

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