Cox models for RR, EFS, and OS using the UKALL prognostic index and original risk definition in the discovery and validation cohorts
| Outcome measure/prognostic factor . | Harrell’s concordance index (95% CI) . | |||
|---|---|---|---|---|
| Discovery cohort . | Validation cohorts . | |||
| EFS | ALL2003 | DCOG-ALL10 | COALL-07-03 | NOPHO-ALL2008 |
| Model 1: PIUKALL, linear variable | 0.73 (0.69-0.76) | 0.68 (0.61-0.74) | 0.70 (0.61-0.78) | 0.70 (0.66-0.75) |
| Model 2: PIUKALL, 4 categories | 0.70 (0.67-0.74) | 0.64 (0.57-0.70) | 0.68 (0.60-0.76) | 0.68 (0.63-0.72) |
| Model 3: Original risk groups | 0.60 (0.57-0.64) | 0.59 (0.52-0.65) | 0.51 (0.43-0.60) | 0.66 (0.62-0.71) |
| RR | ALL2003 | DCOG | COALL | NOPHO |
| Model 1: PIUKALL, linear variable | 0.74 (0.70-0.77) | 0.68 (0.61-0.75) | 0.69 (0.60-0.79) | 0.76 (0.72-0.81) |
| Model 2: PIUKALL, 4 categories | 0.72 (0.68-0.75) | 0.64 (0.57-0.71) | 0.69 (0.59-0.78) | 0.73 (0.69-0.78) |
| Model 3: Original risk groups | 0.61 (0.57-0.64) | 0.55 (0.49-0.62) | 0.50 (0.41-0.59) | 0.68 (0.62-0.73) |
| OS | ALL2003 | DCOG | COALL | NOPHO |
| Model 1: PIUKALL, linear variable | 0.79 (0.75-0.82) | 0.73 (0.65-0.81) | 0.83 (0.76-0.90) | 0.74 (0.68-0.80) |
| Model 2: PIUKALL, 4 categories | 0.76 (0.72-0.80) | 0.67 (0.58-0.77) | 0.80 (0.71-0.89) | 0.73 (0.67-0.79) |
| Model 3: Original risk groups | 0.65 (0.61-0.69) | 0.67 (0.59-0.74) | 0.59 (0.48-0.70) | 0.70 (0.64-0.76) |
| Outcome measure/prognostic factor . | Harrell’s concordance index (95% CI) . | |||
|---|---|---|---|---|
| Discovery cohort . | Validation cohorts . | |||
| EFS | ALL2003 | DCOG-ALL10 | COALL-07-03 | NOPHO-ALL2008 |
| Model 1: PIUKALL, linear variable | 0.73 (0.69-0.76) | 0.68 (0.61-0.74) | 0.70 (0.61-0.78) | 0.70 (0.66-0.75) |
| Model 2: PIUKALL, 4 categories | 0.70 (0.67-0.74) | 0.64 (0.57-0.70) | 0.68 (0.60-0.76) | 0.68 (0.63-0.72) |
| Model 3: Original risk groups | 0.60 (0.57-0.64) | 0.59 (0.52-0.65) | 0.51 (0.43-0.60) | 0.66 (0.62-0.71) |
| RR | ALL2003 | DCOG | COALL | NOPHO |
| Model 1: PIUKALL, linear variable | 0.74 (0.70-0.77) | 0.68 (0.61-0.75) | 0.69 (0.60-0.79) | 0.76 (0.72-0.81) |
| Model 2: PIUKALL, 4 categories | 0.72 (0.68-0.75) | 0.64 (0.57-0.71) | 0.69 (0.59-0.78) | 0.73 (0.69-0.78) |
| Model 3: Original risk groups | 0.61 (0.57-0.64) | 0.55 (0.49-0.62) | 0.50 (0.41-0.59) | 0.68 (0.62-0.73) |
| OS | ALL2003 | DCOG | COALL | NOPHO |
| Model 1: PIUKALL, linear variable | 0.79 (0.75-0.82) | 0.73 (0.65-0.81) | 0.83 (0.76-0.90) | 0.74 (0.68-0.80) |
| Model 2: PIUKALL, 4 categories | 0.76 (0.72-0.80) | 0.67 (0.58-0.77) | 0.80 (0.71-0.89) | 0.73 (0.67-0.79) |
| Model 3: Original risk groups | 0.65 (0.61-0.69) | 0.67 (0.59-0.74) | 0.59 (0.48-0.70) | 0.70 (0.64-0.76) |
EFS, event-free survival; OS, overall survival; RR, relapse rate.