Treatment outcomes CR/CRi, ED, and 2-year OS of all patients stratified for TDT groups and age ≤60 years vs >60 years
| Parameter . | All TDTs . | TDT, 0-5 d . | TDT, 6-10 d . | TDT, 11-15 d . | TDT, >15 d . |
|---|---|---|---|---|---|
| All patients | |||||
| CR/CRi, no./no. available (%) [CI] | 1771/2263 (78.3) [76.5-79.9] | 1229/1547 (79.4) [77.3-81.4] | 341/447 (76.3) [72.1-80.2] | 76/106 (71.7) [62.1-80] | 125/163 (76.7) [69.4-82.9] |
| ED, no./no. available (%) [CI] | 93/2263 (4.1) [3.3-5] | 64/1547 (4.1) [3.2-5.3] | 17/447 (3.8) [2.2-6] | 5/106 (4.7) [1.5-10.7] | 7/163 (4.3) [1.7-8.6] |
| 2-y OS, % [CI] | 50.2 [48.1-52.4] | 51.3 [48.8-54] | 47.5 [43-52.6] | 44.1 [35.1-55.3] | 50.2 [42.9-58.7] |
| Age ≤60 y | |||||
| CR/CRi, no./no. available (%) [CI] | 1048/1212 (86.5) [84.4-88.3] | 771/872 (88.4) [86.1-90.5] | 176/211 (83.4) [77.7-88.2] | 37/47 (78.7) [64.3-89.3] | 64/82 (78) [67.5-86.4] |
| ED, no./no. available (%) [CI] | 31/1212 (2.6) [1.7-3.6] | 20/872 (2.3) [1.4-3.5] | 7/211 (3.3) [1.3-6.7] | 2/47 (4.3) [0.5-14.5] | 2/82 (2.4) [0.3-8.5] |
| 2-y OS, % [CI] | 62.6 [59.8-65.5] | 63.7 [60.5-67.1] | 60.1 [53.6-67.4] | 62.5 [49.7-78.6] | 57.1 [47.1-69.3] |
| Age >60 y | |||||
| CR/CRi, no./no. available (%) [CI] | 723/1051 (68.8) [65.9-71.6] | 458/675 (67.9) [64.2-71.4] | 165/236 (69.9) [63.6-75.7] | 39/59 (66.1) [52.6-77.9] | 61/81 (75.3) [64.5-84.2] |
| ED, no./no. available (%) [CI] | 62/1051 (5.9) [4.6-7.5] | 44/675 (6.5) [4.8-8.7] | 10/236 (4.2) [2.1-7.7] | 3/59 (5.1) [1.1-14.1] | 5/81 (6.2) [2-13.8] |
| 2-y OS, % [CI] | 36 [33.1-39.1] | 35.4 [31.8-39.3] | 36.5 [30.6-43.4] | 30.6 [20.4-45.9] | 43.6 [33.9-56.1] |
| Parameter . | All TDTs . | TDT, 0-5 d . | TDT, 6-10 d . | TDT, 11-15 d . | TDT, >15 d . |
|---|---|---|---|---|---|
| All patients | |||||
| CR/CRi, no./no. available (%) [CI] | 1771/2263 (78.3) [76.5-79.9] | 1229/1547 (79.4) [77.3-81.4] | 341/447 (76.3) [72.1-80.2] | 76/106 (71.7) [62.1-80] | 125/163 (76.7) [69.4-82.9] |
| ED, no./no. available (%) [CI] | 93/2263 (4.1) [3.3-5] | 64/1547 (4.1) [3.2-5.3] | 17/447 (3.8) [2.2-6] | 5/106 (4.7) [1.5-10.7] | 7/163 (4.3) [1.7-8.6] |
| 2-y OS, % [CI] | 50.2 [48.1-52.4] | 51.3 [48.8-54] | 47.5 [43-52.6] | 44.1 [35.1-55.3] | 50.2 [42.9-58.7] |
| Age ≤60 y | |||||
| CR/CRi, no./no. available (%) [CI] | 1048/1212 (86.5) [84.4-88.3] | 771/872 (88.4) [86.1-90.5] | 176/211 (83.4) [77.7-88.2] | 37/47 (78.7) [64.3-89.3] | 64/82 (78) [67.5-86.4] |
| ED, no./no. available (%) [CI] | 31/1212 (2.6) [1.7-3.6] | 20/872 (2.3) [1.4-3.5] | 7/211 (3.3) [1.3-6.7] | 2/47 (4.3) [0.5-14.5] | 2/82 (2.4) [0.3-8.5] |
| 2-y OS, % [CI] | 62.6 [59.8-65.5] | 63.7 [60.5-67.1] | 60.1 [53.6-67.4] | 62.5 [49.7-78.6] | 57.1 [47.1-69.3] |
| Age >60 y | |||||
| CR/CRi, no./no. available (%) [CI] | 723/1051 (68.8) [65.9-71.6] | 458/675 (67.9) [64.2-71.4] | 165/236 (69.9) [63.6-75.7] | 39/59 (66.1) [52.6-77.9] | 61/81 (75.3) [64.5-84.2] |
| ED, no./no. available (%) [CI] | 62/1051 (5.9) [4.6-7.5] | 44/675 (6.5) [4.8-8.7] | 10/236 (4.2) [2.1-7.7] | 3/59 (5.1) [1.1-14.1] | 5/81 (6.2) [2-13.8] |
| 2-y OS, % [CI] | 36 [33.1-39.1] | 35.4 [31.8-39.3] | 36.5 [30.6-43.4] | 30.6 [20.4-45.9] | 43.6 [33.9-56.1] |